Udenafil

JFDA label: Oxsedo 100mg Tab

Mechanism of Action

Inhibitor of cGMP-specific 3',5'-cyclic phosphodiesterase — Phosphodiesterase 5A inhibitor

Target	Action	Gene / class
cGMP-specific 3',5'-cyclic phosphodiesterase efficacy	INHIBITOR	PDE5A

Indications

Off-label

• Alzheimer Disease
• Dementia, Vascular
• Erectile Dysfunction
• Heart Diseases
• Heart Failure, Diastolic
• Heart Failure, Systolic
• Hypertension, Pulmonary
• Raynaud Disease

Chemistry & Properties

Formula	C25H36N6O4S
Molecular weight	516.67 g/mol
IUPAC name	3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,5-d]pyrimidin-5-yl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-propoxybenzenesulfonamide
CAS	268203-93-6
PubChem CID	135413547
InChIKey	IYFNEFQTYQPVOC-UHFFFAOYSA-N
logP	2.83 (XLogP 3.0)
Polar surface area	122.21 Ų
H-bond acceptors / donors	8 / 2
Drug-likeness (QED)	0.40
Lipinski violations	1

SMILES

CCCOc1ccc(S(=O)(=O)NCCC2CCCN2C)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2B6	Inhibitor	—
CYP2C19	Substrate	—
CYP2D6	Substrate	—
CYP3A4	Substrate	—

Receptor binding (top 1)

Target	Action	Affinity
phosphodiesterase 5A (PDE5A)	Inhibitor	pIC50 8.1

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (2)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Oxsedo	Tablet 100 mg	4 tab	Misk Pharma Pharmaceutical Industries/Jordan	9.950
Oxsedo	Tablet 200 mg	4 tab	Misk Pharma Pharmaceutical Industries/Jordan	16.320