New Release: Alpha testing version has been released.

Phenylephrine

R06A - Antihistamines for systemic use ATC S01GA05 Small molecule approved 1952 Oral Parenteral Topical Natural product

JFDA label: Minims PhenylephrineHCL10% e/d

Indications

Approved

  • Cardiovascular Diseases — cardiovascular disease
  • Eye Manifestations — eye allergy
  • Hemorrhoids — hemorrhoid
  • Nasal Obstruction — Nasal congestion

Off-label

  • Acute Lung Injury
  • Bronchiolitis
  • Cognitive Dysfunction
  • Common Cold
  • Eye Diseases
  • Fecal Incontinence
  • Hypotension
  • Influenza, Human
  • Ischemic Stroke
  • Mydriasis
  • Respiratory Tract Infections
  • Rhinitis, Allergic, Seasonal
  • Shock, Septic
  • Stress Disorders, Post-Traumatic
  • Stroke

Dosing

Source: openFDA

Directions this product does not contain directions or complete warnings for adult use do not give more than directed (see Overdose warning ) measure only with dosing cup provided do not use dosing cup with other products dose as follows or as directed by a doctor children 6 to under 12 years of age: 10 mL in dosing cup provided every 4 hours while symptoms last; do not give more than 5 doses in any 24-hour period children under 6 years of age: do not use

Warnings & Precautions

Source: openFDA

Warnings & Precautions

Warnings Liver warning This product contains acetaminophen. Severe liver damage may occur if your child takes: more than 5 doses in 24 hours, which is the maximum daily amount with other drugs containing acetaminophen Allergy alert Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away. Sore throat warning I f sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. to make a child sleepy with any other product containing diphenhydramine, even one used on the skin in a child who is taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your child's prescription drug contains an MAOI, ask a doctor or pharmacist before giving this product. Ask a doctor before use if the child has liver disease heart disease diabetes high blood pressure thyroid disease glaucoma a breathing problem such as chronic bronchitis persistent or chronic cough such as occurs with asthma cough that occurs with too much phlegm (mucus) Ask a doctor or pharmacist before use if the child is taking the blood thinning drug warfarin taking sedatives or tranquilizers When using this product do not use more than directed (see Overdose warning ) excitability may occur, especially in children marked drowsiness may occur sedatives and tranquilizers may increase drowsiness Stop use and ask a doctor if nervousness, dizziness, or sleeplessness occur pain, nasal congestion, or cough gets worse or lasts more than 5 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur cough comes back, or occurs with fever, rash, or headache that lasts. These could be signs of a serious condition. Keep out of reach of children. Overdose warning Taking more than the recommended dose (overdose) may cause liver damage. I n case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical even if you do not notice any signs or symptoms.

Pregnancy & Lactation

Pregnancy

Lactation

Probably Compatible Hale L2

An alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Chemistry & Properties

2D structure
FormulaC9H13NO2
Molecular weight167.21 g/mol
IUPAC name3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
CAS59-42-7
PubChem CID6041
InChIKeySONNWYBIRXJNDC-VIFPVBQESA-N
logP0.65 (XLogP -0.3)
Polar surface area52.49 Ų
H-bond acceptors / donors3 / 3
Drug-likeness (QED)0.62
Lipinski violations0
SMILESCNC[C@H](O)c1cccc(O)c1

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrantYes

Receptor binding (top 2)

TargetActionAffinity
alpha1B Binding pKi 9.1
alpha1A Binding pKi 7.3

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Drug–drug interactions (100+, DDInter)

Interacting drugSeverityManagement
Amitriptyline major
Amoxapine major
Clomipramine major
Cocaine (nasal) major
Cocaine (topical) major
Desipramine major
Dihydroergotamine major
Doxepin major
Ergometrine major
Ergotamine major
Halothane major
Imipramine major
Iobenguane (I-131) major
Isocarboxazid major
Linezolid major
Methylene blue major
Methylergometrine major
Methysergide major
Nortriptyline major
Ozanimod major
Phenelzine major
Procarbazine major
Protriptyline major
Selegiline major
Tranylcypromine major
Trimipramine major
Acarbose moderate
Acebutolol moderate
Acetohexamide moderate
Albiglutide moderate
Alogliptin moderate
Amphetamine moderate
Arformoterol moderate
Atenolol moderate
Atomoxetine moderate
Atropine moderate
Atropine (ophthalmic) moderate
Belladonna moderate
Benzatropine moderate
Benzphetamine moderate

Showing 40 of 100+.

Registered Products (20)

BrandForm / strengthPackAgentCitizen (JOD)
123 Ped. Syrup Syrup 0.2 mg/ml, 0.2 mg/ml, 20 mg/ml 60 ml Adatco Drug Store 0.830
Lemsip Cold & Flu Lemon Tablet 650 mg, 10 mg 5 tab Nairoukh Drug Store 1.050
Riva D Syrup Syrup 2.5 mg/5 ml, 5 mg/5 ml 100 ml Al-Gadeed Pharmaceutical Industries/JORDAN 1.360
Riva N Syrup Syrup 2.5 mg/5 ml, 6.25 mg/5 ml 100 ml Al-Gadeed Pharmaceutical Industries/JORDAN 1.360
Panda Zokam Tab Tablet 5 mg, 500 mg 20 tab Jordan Sweden Medical & Sterilization Co. 1.600
Daywell syrup Syrup 2.5 mg/5 ml, 50 mg/5 ml 120 ml Jordan Sweden Medical & Sterilization Co. 1.630
Vibrocil Drops Oral Drops 0.25 mg/ml, 2.5 mg/ml 15 ml Sukhtian Group 1.640
VIBROCIL GEL Gel 0.25 mg/g, 2.5 mg/g 12 g tube Sukhtian Group 1.830
Vapicil Solution 0.025 %, 0.25 % 15 ml Amman Pharmaceutical Indusries 1.980
Triaminic Chest And Nasal Congestion Syrup Syrup 2.5 mg/5 ml, 50 mg/5 ml 118 ml Nabulsi Drug Store 2.000
Triaminic Day Time Cold And Cough Syrup Syrup 2.5 mg/5 ml, 5 mg/5 ml 118 ml Nabulsi Drug Store 2.000
Triaminic Night Time Cold & Cough Syrup Syrup 2.5 mg/5 ml, 6.25 mg/5 ml 118 ml Nabulsi Drug Store 2.000
Lemsip cold & flu lemon Tablet 650 mg, 10 mg 10 tab Nairoukh Drug Store 2.110
panadol cold & flu day (500 mg , 5 mg , 25 mg ) Tablet 500 mg, 5 mg, 25 mg 24 Caplet Sukhtian Group 2.280
VIBROCIL MD SPRAY Spray 0.25 mg/ml, 2.5 mg/ml 15 ml Sukhtian Group 2.470
Panadol Cold and Flu All n one Tablet 250 mg, 5 mg, 100 mg 24 tab Sukhtian Group 2.640
Panadol Cold & Flu Vapour Release +Decongestant Sachet 600 mg, 10 mg 10 sachet Sukhtian Group 3.310
Minims PhenylephrineHCL10% e/d Ophthalmic Solution 10 % 0.5 ml Petra Drug Store
Phenylephrin Sintetica Ampoule 10 mg/1 ml 10 amp Al Namareq Drug Stores
Phenylephrin Sintetica 0.1 mg /ml Ampoule 0.1 mg/1 ml 10 amp Sun Set Drug Store