Phenylephrine
JFDA label: Minims PhenylephrineHCL10% e/d
Indications
Approved
- Cardiovascular Diseases — cardiovascular disease
- Eye Manifestations — eye allergy
- Hemorrhoids — hemorrhoid
- Nasal Obstruction — Nasal congestion
Off-label
- Acute Lung Injury
- Bronchiolitis
- Cognitive Dysfunction
- Common Cold
- Eye Diseases
- Fecal Incontinence
- Hypotension
- Influenza, Human
- Ischemic Stroke
- Mydriasis
- Respiratory Tract Infections
- Rhinitis, Allergic, Seasonal
- Shock, Septic
- Stress Disorders, Post-Traumatic
- Stroke
Dosing
Source: openFDA
Warnings & Precautions
Source: openFDA
Warnings & Precautions
Warnings Liver warning This product contains acetaminophen. Severe liver damage may occur if your child takes: more than 5 doses in 24 hours, which is the maximum daily amount with other drugs containing acetaminophen Allergy alert Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away. Sore throat warning I f sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. to make a child sleepy with any other product containing diphenhydramine, even one used on the skin in a child who is taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your child's prescription drug contains an MAOI, ask a doctor or pharmacist before giving this product. Ask a doctor before use if the child has liver disease heart disease diabetes high blood pressure thyroid disease glaucoma a breathing problem such as chronic bronchitis persistent or chronic cough such as occurs with asthma cough that occurs with too much phlegm (mucus) Ask a doctor or pharmacist before use if the child is taking the blood thinning drug warfarin taking sedatives or tranquilizers When using this product do not use more than directed (see Overdose warning ) excitability may occur, especially in children marked drowsiness may occur sedatives and tranquilizers may increase drowsiness Stop use and ask a doctor if nervousness, dizziness, or sleeplessness occur pain, nasal congestion, or cough gets worse or lasts more than 5 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur cough comes back, or occurs with fever, rash, or headache that lasts. These could be signs of a serious condition. Keep out of reach of children. Overdose warning Taking more than the recommended dose (overdose) may cause liver damage. I n case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical even if you do not notice any signs or symptoms.
Pregnancy & Lactation
Pregnancy
Lactation
An alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Chemistry & Properties
| Formula | C9H13NO2 |
|---|---|
| Molecular weight | 167.21 g/mol |
| IUPAC name | 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol |
| CAS | 59-42-7 |
| PubChem CID | 6041 |
| InChIKey | SONNWYBIRXJNDC-VIFPVBQESA-N |
| logP | 0.65 (XLogP -0.3) |
| Polar surface area | 52.49 Ų |
| H-bond acceptors / donors | 3 / 3 |
| Drug-likeness (QED) | 0.62 |
| Lipinski violations | 0 |
SMILES
CNC[C@H](O)c1cccc(O)c1Biology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | Yes |
|---|
Receptor binding (top 2)
| Target | Action | Affinity |
|---|---|---|
| alpha1B | Binding | pKi 9.1 |
| alpha1A | Binding | pKi 7.3 |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Drug–drug interactions (100+, DDInter)
| Interacting drug | Severity | Management |
|---|---|---|
| Amitriptyline | major | |
| Amoxapine | major | |
| Clomipramine | major | |
| Cocaine (nasal) | major | |
| Cocaine (topical) | major | |
| Desipramine | major | |
| Dihydroergotamine | major | |
| Doxepin | major | |
| Ergometrine | major | |
| Ergotamine | major | |
| Halothane | major | |
| Imipramine | major | |
| Iobenguane (I-131) | major | |
| Isocarboxazid | major | |
| Linezolid | major | |
| Methylene blue | major | |
| Methylergometrine | major | |
| Methysergide | major | |
| Nortriptyline | major | |
| Ozanimod | major | |
| Phenelzine | major | |
| Procarbazine | major | |
| Protriptyline | major | |
| Selegiline | major | |
| Tranylcypromine | major | |
| Trimipramine | major | |
| Acarbose | moderate | |
| Acebutolol | moderate | |
| Acetohexamide | moderate | |
| Albiglutide | moderate | |
| Alogliptin | moderate | |
| Amphetamine | moderate | |
| Arformoterol | moderate | |
| Atenolol | moderate | |
| Atomoxetine | moderate | |
| Atropine | moderate | |
| Atropine (ophthalmic) | moderate | |
| Belladonna | moderate | |
| Benzatropine | moderate | |
| Benzphetamine | moderate |
Showing 40 of 100+.
Registered Products (20)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| 123 Ped. Syrup | Syrup 0.2 mg/ml, 0.2 mg/ml, 20 mg/ml | 60 ml | Adatco Drug Store | 0.830 |
| Lemsip Cold & Flu Lemon | Tablet 650 mg, 10 mg | 5 tab | Nairoukh Drug Store | 1.050 |
| Riva D Syrup | Syrup 2.5 mg/5 ml, 5 mg/5 ml | 100 ml | Al-Gadeed Pharmaceutical Industries/JORDAN | 1.360 |
| Riva N Syrup | Syrup 2.5 mg/5 ml, 6.25 mg/5 ml | 100 ml | Al-Gadeed Pharmaceutical Industries/JORDAN | 1.360 |
| Panda Zokam Tab | Tablet 5 mg, 500 mg | 20 tab | Jordan Sweden Medical & Sterilization Co. | 1.600 |
| Daywell syrup | Syrup 2.5 mg/5 ml, 50 mg/5 ml | 120 ml | Jordan Sweden Medical & Sterilization Co. | 1.630 |
| Vibrocil Drops | Oral Drops 0.25 mg/ml, 2.5 mg/ml | 15 ml | Sukhtian Group | 1.640 |
| VIBROCIL GEL | Gel 0.25 mg/g, 2.5 mg/g | 12 g tube | Sukhtian Group | 1.830 |
| Vapicil | Solution 0.025 %, 0.25 % | 15 ml | Amman Pharmaceutical Indusries | 1.980 |
| Triaminic Chest And Nasal Congestion Syrup | Syrup 2.5 mg/5 ml, 50 mg/5 ml | 118 ml | Nabulsi Drug Store | 2.000 |
| Triaminic Day Time Cold And Cough Syrup | Syrup 2.5 mg/5 ml, 5 mg/5 ml | 118 ml | Nabulsi Drug Store | 2.000 |
| Triaminic Night Time Cold & Cough Syrup | Syrup 2.5 mg/5 ml, 6.25 mg/5 ml | 118 ml | Nabulsi Drug Store | 2.000 |
| Lemsip cold & flu lemon | Tablet 650 mg, 10 mg | 10 tab | Nairoukh Drug Store | 2.110 |
| panadol cold & flu day (500 mg , 5 mg , 25 mg ) | Tablet 500 mg, 5 mg, 25 mg | 24 Caplet | Sukhtian Group | 2.280 |
| VIBROCIL MD SPRAY | Spray 0.25 mg/ml, 2.5 mg/ml | 15 ml | Sukhtian Group | 2.470 |
| Panadol Cold and Flu All n one | Tablet 250 mg, 5 mg, 100 mg | 24 tab | Sukhtian Group | 2.640 |
| Panadol Cold & Flu Vapour Release +Decongestant | Sachet 600 mg, 10 mg | 10 sachet | Sukhtian Group | 3.310 |
| Minims PhenylephrineHCL10% e/d | Ophthalmic Solution 10 % | 0.5 ml | Petra Drug Store | — |
| Phenylephrin Sintetica | Ampoule 10 mg/1 ml | 10 amp | Al Namareq Drug Stores | — |
| Phenylephrin Sintetica 0.1 mg /ml | Ampoule 0.1 mg/1 ml | 10 amp | Sun Set Drug Store | — |