Nicotinamide
A11E - Vitamin B-complex, incl. combinations
ATC A11E
Small molecule
approved 1982
Oral
Parenteral
Natural product
JFDA label: Vitadad B. Forte Tablet
Mechanism of Action
Used by the body as a source of niacin; is a component of two coenzymes which is necessary for tissue respiration, lipid metabolism, and glycogenolysis; does not have hypolipidemia or vasodilating effects.
Indications
Off-label
- Pellagra (treatment/prophylaxis)
Contraindications
Source: Lexicomp
- Hypersensitivity to niacin, niacinamide, or any component of the formulation Absolute
Dosing
Source: Lexicomp
Pellagra (off-label use): Oral: 100 mg every 6 hours for several days (or until resolution of major signs and symptoms), followed by 50 mg every 8-12 hours until skin lesions heal (Hegyi, 2004)
Pellagra (off-label use): Oral: 10-50 mg every 6 hours until resolution of signs and symptoms (Hegyi, 2004)
Refer to adult dosing.
Pregnancy & Lactation
Pregnancy
Water-soluble vitamins cross the placenta (IOM, 1998).
Chemistry & Properties
| Formula | C6H6N2O |
|---|---|
| Molecular weight | 122.13 g/mol |
| IUPAC name | pyridine-3-carboxamide |
| CAS | 98-92-0 |
| PubChem CID | 936 |
| InChIKey | DFPAKSUCGFBDDF-UHFFFAOYSA-N |
| logP | 0.18 (XLogP -0.4) |
| Polar surface area | 55.98 Ų |
| H-bond acceptors / donors | 2 / 1 |
| Drug-likeness (QED) | 0.58 |
| Lipinski violations | 0 |
SMILES
NC(=O)c1cccnc1Biology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | Yes |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| AOX | Substrate | — |
| CYP1A2 | Substrate | — |
| CYP2C8 | Inhibitor | — |
| CYP2C9 | Substrate | — |
| CYTOCHROME P450S | Substrate | — |
| NNMT | Substrate | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OCT1 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Drug–drug interactions (64, DDInter)
| Interacting drug | Severity | Management |
|---|---|---|
| Leflunomide | major | |
| Lomitapide | major | |
| Mipomersen | major | |
| Pexidartinib | major | |
| Teriflunomide | major | |
| Acarbose | moderate | |
| Albiglutide | moderate | |
| Alogliptin | moderate | |
| Asparaginase Erwinia chrysanthemi | moderate | |
| Asparaginase Escherichia coli | moderate | |
| Bedaquiline | moderate | |
| Brentuximab vedotin | moderate | |
| Calaspargase pegol | moderate | |
| Canagliflozin | moderate | |
| Cannabidiol | moderate | |
| Chlorpropamide | moderate | |
| Clofarabine | moderate | |
| Dapagliflozin | moderate | |
| Dulaglutide | moderate | |
| Efavirenz | moderate | |
| Empagliflozin | moderate | |
| Epirubicin | moderate | |
| Ertugliflozin | moderate | |
| Exenatide | moderate | |
| Glimepiride | moderate | |
| Glipizide | moderate | |
| Glyburide | moderate | |
| Idelalisib | moderate | |
| Insulin aspart (aspart) | moderate | |
| Insulin degludec | moderate | |
| Insulin detemir | moderate | |
| Insulin glargine | moderate | |
| Insulin glulisine | moderate | |
| Insulin human (inhalation, rapid acting) | moderate | |
| Insulin human (isophane) | moderate | |
| Insulin human (regular) | moderate | |
| Insulin human (zinc extended) | moderate | |
| Insulin human (zinc) | moderate | |
| Insulin lispro | moderate | |
| Interferon beta-1a | moderate |
Showing 40 of 64.
Registered Products (9)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Vitadad B. Forte Tablet | Tablet 50 mg, 25 mg, 0.15 mg, 15 mg, 15 mg, 10 mg, 10 mcg | 30 tab pack varies | Dar Al Dawa Development and Investment Co Ltd/Jordan | 2.000 |
| Ironorm Capsules | Capsule 1.7 mg, 10 mg, 15 mg, 2 mg, 195 mg, 1.00 mg | 25 cap pack varies | AL Razi Drug Store | 2.060 |
| BECOZYM FORTE TAB | Tablet 50 mg, 25 mg, 0.15 mg, 0.01 mg, 10 mg, 15 mg, 15 mg | 20 tab | The Jordan Drugstore Co | 2.270 |
| Pronatal | Tablet 0.6 mg, 2.6 mcg, 18 mg, 0.03 mg, 2 mg, 85 mg, 15 mg, 0.06 mg, 150 mg, 0.03 mg, 0.2 mg, 0.05 mg, 11 mg, 1.9 mg, 27 mg, 1 mg, 53 mg, 1.4 mg, 200 IU, 1.4 mg | 30 tab | THE ARAB DRUG STORE P.S.C | 5.570 |
| Pharmaton Capsules | Capsule 20 mg, 15 mg, 10 mg, 60 mg, 400 IU, 2 mg, 4000 IU, 1 mcg, 90.3 mg, 1 mg, 10 mg, 1 mg, 10 mg, 40 mg, 10 mg, 1 mg, 2 mg, 8 mg, 66 mg, 1 mg, 26 mg, 70 mg, 0.2 mg | 30 cap | THE ARAB DRUG STORE P.S.C | 6.700 |
| Ironorm Capsules | Capsule 1.7 mg, 10 mg, 15 mg, 2 mg, 195 mg, 1.00 mg | 100 cap pack varies | AL Razi Drug Store | 7.690 |
| Elevit Pronatal film-coated tablets | Film-Coated Tablet 0.80 mg, 4.00 mcg, 19.00 mg, 10.00 mg, 200 mcg, 100.00 mg, 1080 mcg, 12.5 mcg, 125.00 mg, 7.50 mg, 2.60 mg, 60.00 mg, 1.00 mg, 125 mg, 1.00 mg, 1.80 mg, 100.00 mg, 1.60 mg, 15.00 mg | 30 tab | The Jordan Drugstore Co | 8.330 |
| Vitadad B Forte Tablet | Tablet 50 mg, 25 mg, 0.15 mg, 15 mg, 15 mg, 10 mg, 10 mcg | 300 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 18.000 |
| Vitadad B. Forte Tablet | Tablet 50 mg, 25 mg, 0.15 mg, 15 mg, 15 mg, 10 mg, 10 mcg | 500 tab pack varies | Dar Al Dawa Development and Investment Co Ltd/Jordan | 29.000 |