Thiopental

JFDA label: Thiopental Vial

Indications

Off-label

• Brain Injuries
• Shock, Septic
• Status Epilepticus
• Strabismus

Pregnancy & Lactation

Chemistry & Properties

Formula	C11H18N2O2S
Molecular weight	242.34 g/mol
IUPAC name	5-ethyl-5-pentan-2-yl-2-sulfanylidene-1,3-diazinane-4,6-dione
CAS	76-75-5
PubChem CID	3000715
InChIKey	IUJDSEJGGMCXSG-UHFFFAOYSA-N
logP	1.35 (XLogP 2.9)
Polar surface area	58.2 Ų
H-bond acceptors / donors	3 / 2
Drug-likeness (QED)	0.58
Lipinski violations	0

SMILES

CCCC(C)C1(CC)C(=O)NC(=S)NC1=O

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	Yes (logBB -0.1)

Enzyme interactions

Enzyme	Role	Detail
CYP2C19	Substrate	—
CYP2C8	Inhibitor	—
CYP2C9	Inhibitor	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)MDR1 (Substrate)P-gp (Substrate)

Drug–drug interactions (44, DDInter)

Interacting drug	Severity	Management
Ethanol	major
Warfarin	major
Aldesleukin	moderate
Aminophylline	moderate
Brimonidine (ophthalmic)	moderate
Brimonidine (topical)	moderate
Carbinoxamine	moderate
Cetirizine	moderate
Clemastine	moderate
Clofedanol	moderate
Codeine	moderate
Cyclosporine	moderate
Cyproheptadine	moderate
Dexbrompheniramine	moderate
Dextromethorphan	moderate
Diphenhydramine	moderate
Doxepin	moderate
Doxepin (topical)	moderate
Doxycycline	moderate
Doxylamine	moderate
Dronabinol	moderate
Griseofulvin	moderate
Hydrocodone	moderate
Ifosfamide	moderate
Iodide I-123	moderate
Iodide I-131	moderate
Levocetirizine	moderate
Mepyramine	moderate
Methylene blue	moderate
Morphine	moderate
Nabilone	moderate
Nitisinone	moderate
Olopatadine (nasal)	moderate
Ozanimod	moderate
Pentoxyverine	moderate
Procarbazine	moderate
Thalidomide	moderate
Theophylline	moderate
Trimethobenzamide	moderate
Cimetidine	minor

Showing 40 of 44.

Registered Products (2)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Thiopental Vial	Vial 1 g	25 vial	Nabulsi Drug Store	—
Thiosol	Vial 1 g	1 vial	AL Rahma Drug Store	—