beclometasone and antibiotics

JFDA label: Menaderm Cream

Chemistry & Properties

Formula	C28H37ClO7
Molecular weight	521.0 g/mol
IUPAC name	[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate
CAS	5534-09-8
PubChem CID	21700
InChIKey	KUVIULQEHSCUHY-XYWKZLDCSA-N
logP	3.0 (XLogP 3.0)
Polar surface area	107.0 Ų
H-bond acceptors / donors	7 / 1

SMILES

CCC(=O)OCC(=O)C1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)Cl)O)C)C)OC(=O)CC

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	Yes

Enzyme interactions

Enzyme	Role	Detail
CYP2B6	Inhibitor	—
CYP2C8	Inhibitor	—
CYP3A4	Inhibitor	—
CYP3A4	Substrate	—

Receptor binding (top 1)

Target	Action	Affinity
ADGRG3 (ADGRG3)	Agonist	pEC50 8.5

Transporters

BCRP (Inhibitor)BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP1B3 (Inhibitor)OCT1 (Inhibitor)OCT2 (Inhibitor)P-gp (Inhibitor)MDR1 (Substrate)P-gp (Substrate)

Drug–drug interactions (48, DDInter)

Interacting drug	Severity	Management
Brexucabtagene autoleucel	major
Desmopressin	major
Dinutuximab	major
Mifepristone	major
Upadacitinib	major
Acetazolamide	moderate
Amphotericin B	moderate
Amphotericin B (cholesteryl sulfate)	moderate
Amphotericin B (lipid complex)	moderate
Amphotericin B (liposomal)	moderate
Bendroflumethiazide	moderate
Benzthiazide	moderate
Bumetanide	moderate
Capreomycin	moderate
Chlorothiazide	moderate
Chlorthalidone	moderate
Cisplatin	moderate
Diclofenamide	moderate
Etacrynic acid	moderate
Foscarnet	moderate
Furosemide	moderate
Hydrochlorothiazide	moderate
Hydroflumethiazide	moderate
Indapamide	moderate
Indium In-111 oxyquinoline	moderate
Insulin human (inhalation, rapid acting)	moderate
Methazolamide	moderate
Metolazone	moderate
Omacetaxine mepesuccinate	moderate
Patiromer	moderate
Polythiazide	moderate
Tolevamer	moderate
Torasemide	moderate
Trichlormethiazide	moderate
Arformoterol	minor
Formoterol	minor
Indacaterol	minor
Isoetharine	minor
Isoprenaline	minor
Levosalbutamol	minor

Showing 40 of 48.

Registered Products (3)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Menaderm Cream	Cream 0.025 %, 0.5 %	30 g tube pack varies	ORIENT DRUG STORE CO	1.670
Menaderm Lotion	Lotion 0.025 %, 0.5 %	30 g pack varies	ORIENT DRUG STORE CO	1.670
Foster	Tablet 100 mcg, 6 mcg	1 Can X 120 dose	Kurdi Drug Store	22.300