Mecobalamin
B03B - Vitamin B12 and folic acid
ATC B03BA05
Small molecule
Natural product
JFDA label: Pancobamin 1ml Amp
Indications
Approved
- Anemia — anemia (phenotype)
Off-label
- Amyotrophic Lateral Sclerosis
- Diabetes Mellitus, Type 2
- Hand-Foot Syndrome
- Vitamin B 12 Deficiency
Chemistry & Properties
| Formula | C63H91CoN13O14P |
|---|---|
| Molecular weight | 1344.4 g/mol |
| IUPAC name | carbanide;cobalt(3+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(1R,2R,3R,5Z,7S,10Z,12S,13S,15Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-24-id-3-yl]propanoylamino]propan-2-yl phosphate |
| CAS | 13422-55-4 |
| PubChem CID | 10898559 |
Biology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 10.0% |
|---|---|
| Half-life | 1.035 h |
| Volume of distribution | 0.487 L/kg |
| Protein binding | 76.0% |
| BBB penetrant | No |
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP2C19 | Substrate | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Drug–drug interactions (13, DDInter)
| Interacting drug | Severity | Management |
|---|---|---|
| Arsenic trioxide | moderate | |
| Chloramphenicol | moderate | |
| Cimetidine | minor | |
| Dexlansoprazole | minor | |
| Esomeprazole | minor | |
| Famotidine | minor | |
| Lansoprazole | minor | |
| Nizatidine | minor | |
| Omeprazole | minor | |
| Pantoprazole | minor | |
| Rabeprazole | minor | |
| Ranitidine | minor | |
| Ranitidine (bismuth citrate) | minor |
Registered Products (17)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Pancobamin Capsules | Capsule 500 mcg | 30 cap pack varies | AL Rahma Drug Store | 4.220 |
| Cobal | Tablet 500 mcg | 30 tab pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 4.270 |
| Cobal ODT | Tablet 500 mcg | 30 tab | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 4.270 |
| Nervamine Tab | Tablet 500 mcg | 30 tab pack varies | Pharma International Company/ Jordan | 4.270 |
| Twilvib | Tablet 500 mcg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 4.270 |
| subli-12 | Tablet 0.5 mg | 30 tab pack varies | Sana Pharmaceutical Industry / Sana Pharmaceutical Industry / Not Determined | 4.750 |
| Methycobal Tab | Tablet 500 mcg | 30 tab pack varies | AL-TAQADDOM PHARMACEUTICAL INDUSTRIES/JORDAN | 5.280 |
| Cobal | Ampoule 500 mcg | 8 amp pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 7.370 |
| Subli-12 | Tablet 1 mg | 30 tab | SANA PHARMACEUTICAL INDUSTRY/JORDAN | 7.790 |
| Pancobamin | Ampoule 500 mcg | 10 amp pack varies | AL Rahma Drug Store | 9.210 |
| Methycobal Amp | Ampoule 500 mcg | 10 | Misk Pharma Pharmaceutical Industries/Jordan | 10.130 |
| Nervamine Tab | Tablet 500 mcg | 100 tab pack varies | Pharma International Company/ Jordan | 13.380 |
| subli-12 | Tablet 0.5 mg | 90 tab pack varies | Sana Pharmaceutical Industry / Sana Pharmaceutical Industry / Not Determined | 13.400 |
| Cobal | Tablet 500 mcg | 105 tab pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 14.050 |
| Methycobal Tab | Tablet 500 mcg | 100 tab pack varies | AL-TAQADDOM PHARMACEUTICAL INDUSTRIES/JORDAN | 16.540 |
| Pancobamin | Ampoule 500 mcg | 100 amp pack varies | AL Rahma Drug Store | 50.220 |
| Pancobamin Capsules | Capsule 500 mcg | 500 cap pack varies | AL Rahma Drug Store | 61.190 |