Ritodrine

JFDA label: Ritorin 5ml Amp

Chemistry & Properties

Formula	C17H21NO3
Molecular weight	287.36 g/mol
IUPAC name	4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol
CAS	26652-09-5
PubChem CID	33572
InChIKey	IOVGROKTTNBUGK-UHFFFAOYSA-N
logP	2.35 (XLogP 2.3)
Polar surface area	72.72 Ų
H-bond acceptors / donors	4 / 4
Drug-likeness (QED)	0.66
Lipinski violations	0

SMILES

CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability	70.0%
Half-life	1.997 h
Volume of distribution	5.845 L/kg
Protein binding	38.6%
BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2C19	Substrate	—
CYP2C8	Inhibitor	—
CYP2D6	Inhibitor	—
CYP2D6	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)MRP2 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Drug–drug interactions (100+, DDInter)

Interacting drug	Severity	Management
Anagrelide	major
Arsenic trioxide	major
Cabozantinib	major
Ceritinib	major
Cocaine (nasal)	major
Cocaine (topical)	major
Crizotinib	major
Dolasetron	major
Ivosidenib	major
Lumefantrine	major
Macimorelin	major
Nilotinib	major
Osimertinib	major
Ozanimod	major
Panobinostat	major
Pasireotide	major
Ribociclib	major
Toremifene	major
Vandetanib	major
Vemurafenib	major
Abiraterone	moderate
Acarbose	moderate
Albiglutide	moderate
Alogliptin	moderate
Aminophylline	moderate
Apalutamide	moderate
Bicalutamide	moderate
Bosutinib	moderate
Canagliflozin	moderate
Chloroquine	moderate
Chlorpropamide	moderate
Cilostazol	moderate
Clarithromycin	moderate
Dapagliflozin	moderate
Dasatinib	moderate
Daunorubicin	moderate
Daunorubicin (liposomal)	moderate
Degarelix	moderate
Diethylpropion	moderate
Doxapram	moderate

Showing 40 of 100+.

Registered Products (1)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Ritorin	Ampoule 10 mg/ml	10 amp	AL Rahma Drug Store	22.240