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Magnesium Hydroxide

A02A - Antacids ATC A-02-A1 Small molecule approved 2000 Oral

JFDA label: Aloxal Suspension

Mechanism of Action

— Saline laxative

Indications

Approved

  • Antacid
  • Laxative (occasional constipation)

Contraindications

Source: Lexicomp

  • Hypersensitivity to any ingredient Absolute

Dosing

Source: Lexicomp

Antacid: OTC labeling: Oral: Liquid: Magnesium hydroxide 400 mg/5 mL: 5 to 15 mL as needed up to 4 times/day; do not exceed 60 mL in 24 hours Tablet, chewable: Magnesium hydroxide 311 mg/tablet: 2 to 4 tablets every 4 hours up to 4 times/day; do not exceed 4 doses in 24 hours Laxative (occasional constipation): OTC labeling: Oral: Liquid: Magnesium hydroxide 400 mg/5 mL: 30 to 60 mL/day once daily at bedtime or in divided doses Magnesium hydroxide 800 mg/5 mL: 15 to 30 mL/day once daily at bedtime or in divided doses Magnesium hydroxide 1,200 mg/5 mL: 10 to 20 mL/day once daily at bedtime or in divided doses Tablet, chewable: Magnesium hydroxide 311 mg/tablet: 8 tablets/day once daily at bedtime or in divided doses
(For additional information see "Magnesium hydroxide: Pediatric drug information") Antacid: OTC labeling: Oral: Liquid: Magnesium hydroxide 400 mg/5 mL: Children ≥12 years: Refer to adult dosing. Tablet, chewable: Magnesium hydroxide 311 mg/tablet: Children Children ≥12 years: Refer to adult dosing. Laxative (occasional constipation): Oral: Liquid: OTC labeling: Children Children 2 to 5 years: Magnesium hydroxide 400 mg/5 mL: 5 to 15 mL/day once daily at bedtime or in divided doses Children 6 to 11 years: Magnesium hydroxide 400 mg/5 mL: 15 to 30 mL/day once daily at bedtime or in divided doses Magnesium hydroxide 1,200 mg/5 mL: 5 to 10 mL/day once daily at bedtime or in divided doses Children ≥12 years: Refer to adult dosing. Tablet, chewable: OTC labeling: Magnesium hydroxide 311 mg/tablet: Children Children 3 to 5 years: 2 tablets/day once daily at bedtime or in divided doses Children 6 to 11 years: 4 tablets/day once daily at bedtime or in divided doses Children ≥12 years: Refer to adult dosing. Magnesium hydroxide 400 mg/tablet: Children Children 2 to 5 years: 1 to 3 tablets/day once daily or in divided doses (maximum daily dose: 3 tablets) Children 6 to 11 years: 3 to 6 tablets/day once daily or in divided doses (maximum daily dose: 6 tablets)
Refer to adult dosing.
There are no dosage adjustments provided in the manufacturer's labeling; however, patients in severe renal failure should not receive magnesium due to toxicity from accumulation. Patients with a CrCl
There are no dosage adjustments provided in manufacturer's labeling.

Warnings & Precautions

Source: Lexicomp

Neuromuscular disease

Use with extreme caution in patients with myasthenia gravis or other neuromuscular disease.

Renal impairment

Use with caution in patients with renal impairment; accumulation of magnesium may lead to magnesium intoxication. Other warnings/precautions:

OTC use

For occasional use only; serious side effects may occur with prolonged use. For use only under the supervision of a health care provider in patients with kidney dysfunction, a magnesium-restricted diet, stomach pain/nausea/vomiting, or with a sudden change in bowel habits which persist for >2 weeks. Patients should stop use as a laxative and notify health care provider of any rectal bleeding, if bowel movement does not occur after using product, or if use is needed for >1 week. Stop use as an antacid and notify health care provider if you have taken the maximum dose for >2 weeks. Not for OTC use in children

Pregnancy & Lactation

Pregnancy

Magnesium crosses the placenta; serum concentrations in the fetus are similar to those in the mother (Idama 1998; Osada 2002). The American Gastroenterological Association considers the use of magnesium containing antacids to be low risk in pregnancy (Mahadevan 2006).

Lactation

Magnesium is found in breast milk; concentrations remain constant during the first year of lactation and are not influenced by dietary intake under normal conditions (IOM 1997).

Chemistry & Properties

2D structure
FormulaH2MgO2
Molecular weight58.32 g/mol
IUPAC namemagnesium dihydroxide
CAS1309-42-8
PubChem CID73981
InChIKeyVTHJTEIRLNZDEV-UHFFFAOYSA-L
SMILES[Mg+2].[OH-].[OH-]

Biology & Pharmacokinetics

Pharmacokinetics

Drug–drug interactions (100+, DDInter)

Interacting drugSeverityManagement
Bictegravir major
Dolutegravir major
Erdafitinib major
Patiromer major
Raltegravir major
Selpercatinib major
Tolevamer major
Abarelix moderate
Abiraterone moderate
Acalabrutinib moderate
Acetazolamide moderate
Acetohexamide moderate
Acetylsalicylic acid moderate
Alendronic acid moderate
Alfuzosin moderate
Amiloride moderate
Amiodarone moderate
Amisulpride moderate
Amphetamine moderate
Amprenavir moderate
Anagrelide moderate
Apalutamide moderate
Apomorphine moderate
Arsenic trioxide moderate
Asenapine moderate
Astemizole moderate
Atazanavir moderate
Atomoxetine moderate
Atropine moderate
Azithromycin moderate
Bacampicillin moderate
Baloxavir marboxil moderate
Bedaquiline moderate
Bendroflumethiazide moderate
Benzphetamine moderate
Benzthiazide moderate
Bepridil moderate
Betamethasone moderate
Bicalutamide moderate
Bisacodyl moderate

Showing 40 of 100+.

Registered Products (16)

BrandForm / strengthPackAgentCitizen (JOD)
Salisal Plus Tablets Tablet 325 mg, 150 mg, 75 mg 10 tab pack varies UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN 0.210
Salisal Plus Tablets Tablet 325 mg, 150 mg, 75 mg 20 tab pack varies UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN 0.400
Stomacid Solution 80 mg, 215 mg 100 ml Reda Jardaneh Drug Store 0.490
Stomacid Tablet 200 mg, 200 mg 20 tab Reda Jardaneh Drug Store 0.610
Moxal Tablet Tablet 100 mg, 405 mg 30 Chew Tab pack varies Professional Drug Store 0.660
Moxal Plus Susp. Suspension 80 mg/5 ml, 215 mg/5 ml, 25 mg/5 ml 100 ml Professional Drug Store 0.720
Aloxal Suspension Suspension 145 mg/5 ml, 375 mg/5 ml 200 ml Sun Set Drug Store 0.830
Laxofin Susp. Suspension 5.8 g/100 ml, 25 g/100 ml 200 ml AL-Faiasel Drug Store 0.840
Moxal Plus (Chewable) Tablet Chewable Tablet 200 mg, 200 mg, 25 mg 30 tab Professional Drug Store 0.850
Maalox Susp. Suspension 3.65 g, 3.25 g 200 ml THE ARAB DRUG STORE P.S.C 1.150
Maalox Plus Susp. Suspension 3.65 g, 3.25 g, 0.5 mg 200 ml THE ARAB DRUG STORE P.S.C 1.780
Maalox TC Susp. Suspension 6 g, 12 g 200 ml THE ARAB DRUG STORE P.S.C 1.920
Maalox TC Tab. Tablet 300 mg, 600 mg 40 tab THE ARAB DRUG STORE P.S.C 1.920
Moxal Tablet Tablet 100 mg, 405 mg 100 Chew Tab pack varies Professional Drug Store 2.080
Salisal Plus Tablets Tablet 325 mg, 150 mg, 75 mg 100 tab pack varies UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN 2.400
Protozol-D Tablets Tablet 250 mg, 300 mg 3x10's The Arab Pharmaceutical Manufactruing Co. 3.700