Streptokinase

JFDA label: STREPTASE VIAL

Mechanism of Action

Activator of Plasminogen — Plasminogen activator

Target	Action	Gene / class
Plasminogen efficacy	ACTIVATOR	PLG

Indications

Approved

• Thrombosis — Recurrent thrombophlebitis

Off-label

• Coronary Disease
• Heart Diseases
• Ischemic Stroke
• Myocardial Infarction
• Myocardial Ischemia
• Pancreatitis
• Venous Thrombosis

Chemistry & Properties

Formula	C11H19NO2
Molecular weight	197.27 g/mol
IUPAC name	4-cyclohexylpyrrolidine-2-carboxylic acid
CAS	9002-01-1
PubChem CID	9815560
InChIKey	XRZWVSXEDRYQGC-UHFFFAOYSA-N
logP	0.3 (XLogP 0.3)
Polar surface area	49.3 Ų
H-bond acceptors / donors	3 / 2

SMILES

C1CCC(CC1)C2CC(NC2)C(=O)O

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability	10.0%
Half-life	1.288 h
Volume of distribution	0.802 L/kg
Protein binding	42.7%
BBB penetrant	No

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Drug–drug interactions (100+, DDInter)

Interacting drug	Severity	Management
Abciximab	major
Acalabrutinib	major
Apixaban	major
Argatroban	major
Avapritinib	major
Betrixaban	major
Bivalirudin	major
Cabozantinib	major
Cangrelor	major
Caplacizumab	major
Dalteparin	major
Dasatinib	major
Deferasirox	major
Defibrotide	major
Desirudin	major
Drotrecogin alfa	major
Edoxaban	major
Enoxaparin	major
Eptifibatide	major
Fondaparinux	major
Heparin	major
Ibritumomab tiuxetan	major
Ibrutinib	major
Inotersen	major
Lepirudin	major
Omacetaxine mepesuccinate	major
Panobinostat	major
Ponatinib	major
Prasugrel	major
Ramucirumab	major
Regorafenib	major
Rivaroxaban	major
Tipranavir	major
Tirofiban	major
Tositumomab (I-131)	major
Vorapaxar	major
Warfarin	major
Zanubrutinib	major
Acetylsalicylic acid	moderate
Aminocaproic acid	moderate

Showing 40 of 100+.

Registered Products (2)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
STREPTASE VIAL	Vial 1500000 IU	1 vial	Sabbagh Drug Store	—
STREPTASE VIAL	Vial 250000 IU	1 vial	Sabbagh Drug Store	—