Castor Oil
A06A - Drugs for constipation
ATC A06AB05
Unknown
JFDA label: Castor Oil
Mechanism of Action
Acts primarily in the small intestine; hydrolyzed to ricinoleic acid which reduces net absorption of fluid and electrolytes and stimulates peristalsis
Indications
Approved
- Bowel evacuation/constipation
Adverse Reactions
Very Common >10%Common 1–10%Uncommon 0.1–1%
Rare 0.01–0.1%Very Rare <0.01%Not Known
Cardiac disorders (1)
Not Known Hypotension
Nervous system disorders (2)
Not Known Dizziness · pelvic congestion syndrome
Metabolism and nutrition disorders (1)
Not Known Electrolyte disturbance
Gastrointestinal disorders (3)
Not Known Abdominal cramps · diarrhea · nausea
Dosing
Source: Lexicomp
Bowel evacuation, constipation: Oil: Oral: 15 to 60 mL as a single dose
(For additional information see "Castor oil: Pediatric drug information") Bowel evacuation, constipation: Oil: Oral: Children 2 to 11 years: 5 to 15 mL as a single dose Children ≥12 years and Adolescents: Refer to adult dosing.
Refer to adult dosing.
Warnings & Precautions
Source: Lexicomp
Appropriate use
Do not use for longer than 1 week or when abdominal pain, nausea, vomiting, or rectal bleeding are present unless directed by health care provider.
Pregnancy & Lactation
Pregnancy
Ingestion of castor oil may be associated with induction of labor. Use of castor oil as a laxative during pregnancy should be avoided (Cullen, 2007; Hall, 2011; Wald, 2003).
Biology & Pharmacokinetics
Pharmacokinetics
Drug–drug interactions (100+, DDInter)
| Interacting drug | Severity | Management |
|---|---|---|
| Abarelix | moderate | |
| Abiraterone | moderate | |
| Acetazolamide | moderate | |
| Alfuzosin | moderate | |
| Alimemazine | moderate | |
| Amiloride | moderate | |
| Amiodarone | moderate | |
| Amisulpride | moderate | |
| Anagrelide | moderate | |
| Apalutamide | moderate | |
| Apomorphine | moderate | |
| Arsenic trioxide | moderate | |
| Asenapine | moderate | |
| Astemizole | moderate | |
| Atomoxetine | moderate | |
| Azithromycin | moderate | |
| Bedaquiline | moderate | |
| Bendroflumethiazide | moderate | |
| Benzthiazide | moderate | |
| Bepridil | moderate | |
| Betamethasone | moderate | |
| Bicalutamide | moderate | |
| Bosutinib | moderate | |
| Bumetanide | moderate | |
| Buprenorphine | moderate | |
| Cabozantinib | moderate | |
| Ceritinib | moderate | |
| Chlorothiazide | moderate | |
| Chlorpromazine | moderate | |
| Chlorthalidone | moderate | |
| Cilostazol | moderate | |
| Ciprofloxacin | moderate | |
| Cisapride | moderate | |
| Citalopram | moderate | |
| Clarithromycin | moderate | |
| Clofazimine | moderate | |
| Clozapine | moderate | |
| Corticotropin | moderate | |
| Crizotinib | moderate | |
| Dasatinib | moderate |
Showing 40 of 100+.
Registered Products (6)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| castor oil | Solution 100 % | 60 ml | MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN | 0.750 |
| Castor Oil | Solution 100 % | 60 ml | Amman Pharmaceutical Indusries | 0.800 |
| Castor Oil BP Liquid | Solution 100 %w/w | 60 ml | PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN | 1.000 |
| Aromatic Castor Oil | Solution 99.012 % | 60 ml | Amman Pharmaceutical Industries Co | 1.150 |
| Castor Oil Aromatic | Solution 100 %w/v | 60 ml | PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN | 1.150 |
| Bilinorm Oral Gel | Gel 2 g, 274 mcg, 13.7 mcg | 45 g tube | The Arab Pharmaceutical Manufactruing Co. | 8.000 |