Amlodipine
C08C - Selective calcium channel blockers with mainly vascular effects
ATC C08CA01
Small molecule
approved 1992
Oral
Natural product
JFDA label: Norvasc Caps
Mechanism of Action
Inhibits calcium ion from entering the “slow channels” or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarization, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation; increases myocardial oxygen delivery in patients with vasospastic angina. Amlodipine directly acts on vascular smooth muscle to produce peripheral arterial vasodilation reducing peripheral vascular resistance and blood pressure.
Indications
Approved
- Angiographically documented CAD
- Chronic kidney disease (CKD) and hypertension
- Chronic stable angina
- Coronary artery disease (CAD)
- Diabetes and hypertension
- Hypertension
- Vasospastic angina (Prinzmetal or variant angina)
Contraindications
Source: Lexicomp · Curated
- Additional contraindications (not in US labeling): Hypersensitivity to other dihydropyridines Absolute
- Cardiogenic shock or severe aortic stenosis with outflow obstruction Absolute
- Hypersensitivity to amlodipine or any component of the formulation Absolute
- severe hypotension (SBP Absolute
Adverse Reactions
Very Common >10%Common 1–10%Uncommon 0.1–1%
Rare 0.01–0.1%Very Rare <0.01%Not Known
Cardiac disorders (4)
Very Common Peripheral edema
Common flushing · Palpitations
Uncommon Palpitations
Vascular disorders (1)
Common Flushing
Nervous system disorders (6)
Common Dizziness · dizziness · drowsiness · Fatigue · Headache · male sexual disorder
Gastrointestinal disorders (4)
Common abdominal pain · Nausea
Uncommon Abdominal pain · Nausea
Skin and subcutaneous tissue disorders (2)
Common Pruritus · skin rash
Musculoskeletal and connective tissue disorders (2)
Common Muscle cramps · weakness
General disorders and administration site conditions (2)
Very Common Peripheral oedema
Common Fatigue
Respiratory, thoracic and mediastinal disorders (2)
Very Common Pulmonary edema
Common Dyspnea
Dosing
Source: Lexicomp
Coronary artery disease (CAD) (chronic stable angina, vasospastic angina, angiographically documented CAD [without heart failure or ejection fraction Oral: 5 to 10 mg once daily Hypertension: Oral: Initial: 5 mg once daily or 2.5 mg once daily in small or frail patients, or when adding amlodipine to other antihypertensive therapy; maximum dose: 10 mg once daily. In general, titrate every 7 to 14 days. Titrate more rapidly, however, if clinically warranted, provided the patient is assessed frequently. Usual dosage range (ASH/ISH [Weber 2014]): 5 to 10 mg once daily. Target dose (JNC8 [James 2013]): 10 mg once daily.
(For additional information see "Amlodipine: Pediatric drug information") Hypertension: Children ≥6 years and Adolescents: Oral: 2.5 to 5 mg once daily
Dosing should start at the lower end of dosing range and titrated to response due to possible increased incidence of hepatic, renal, or cardiac impairment. Elderly patients also show decreased clearance of amlodipine. Coronary artery disease (CAD) (chronic stable angina, vasospastic angina, angiographically documented CAD without heart failure or ejection fraction Oral: Initial: 5 mg once daily Hypertension: Oral: Initial: 2.5 mg once daily; maximum dose: 10 mg once daily. In general, titrate every 7 to 14 days. Titrate more rapidly, however, if clinically warranted, provided the patient is assessed frequently. Usual dosage range (ASH/ISH [Weber 2014]): 5 to 10 mg once daily. Target dose (JNC8 [James 2013]): 10 mg once daily.
No dosage adjustment necessary (Doyle 1989; Kungys 2003). End-stage renal disease (ESRD) on dialysis: Hemodialysis and peritoneal dialysis do not enhance elimination; supplemental dose is not necessary (Kungys 2003).
Coronary artery disease (CAD) (chronic stable angina, vasospastic angina, angiographically documented CAD without heart failure or ejection fraction Hypertension: Initial: 2.5 mg once daily; titrate slowly in patients with severe hepatic impairment.
Warnings & Precautions
Source: Lexicomp
Angina/MI
Increased angina and/or MI have occurred with initiation or dosage titration of dihydropyridine calcium channel blockers. Reflex tachycardia may occur resulting in angina and/or MI in patients with obstructive coronary disease, especially in the absence of concurrent beta-blockade.
Hypotension
Symptomatic hypotension can occur; acute hypotension upon initiation is unlikely due to the gradual onset of action. Blood pressure must be lowered at a rate appropriate for the patient's clinical condition.
Peripheral edema
The most common side effect is peripheral edema; occurs within 2 to 3 weeks of starting therapy. Disease-related concerns:
Aortic stenosis
Use amlodipine with extreme caution in patients with severe aortic stenosis; may reduce coronary perfusion resulting in ischemia.
Hepatic impairment
Use with caution in patients with hepatic impairment; may require lower starting dose; titrate slowly in patients with severe hepatic impairment.
Hypertrophic cardiomyopathy (HCM) with outflow tract obstruction
Use amlodipine with caution in patients with HCM and outflow tract obstruction since reduction in afterload may worsen symptoms associated with this condition (ACCF/AHA [Gersh 2011]). Special populations:
Elderly
Initiate at a lower dose in the elderly. Other warnings/precautions:
Titration
Peak antihypertensive effect is delayed; dosage titration should occur after 7 to 14 days on a given dose.
Pregnancy & Lactation
Pregnancy
FDA category C
Caution
Nifedipine is preferred calcium channel blocker in pregnancy (more data available)
Lactation
RID 4.18%
Amlodipine is present in breast milk. The relative infant dose (RID) of amlodipine is 4.18 % (interquartile range 3.12% to 7.25%) when calculated using a median breast milk concentration and compared to a weight adjusted maternal dose of 6.01 mg ± 2.31 mg/day. In general, breastfeeding is considered acceptable when the RID is 25% breastfeeding should generally be avoided (Anderson 2016; Ito 2000). Using a median predose milk concentration (11.5 ng/mL; IQR 9.84 to 18 ng/mL), authors of a study
Monitoring
| Efficacy | Blood pressure (target varies by indication); resting heart rate |
|---|---|
| Toxicity | Ankle oedema; headache; flushing |
| Clinical pearl | Once-daily dosing achieves smooth 24-h blood pressure control. Full antihypertensive effect may take 1–2 weeks. |
| Counseling | Monitor blood pressure at home if possible. Report severe ankle swelling or persistent headache. |
Chemistry & Properties
| Formula | C20H25ClN2O5 |
|---|---|
| Molecular weight | 408.88 g/mol |
| IUPAC name | 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| CAS | 88150-42-9 |
| PubChem CID | 2162 |
| InChIKey | HTIQEAQVCYTUBX-UHFFFAOYSA-N |
| logP | 2.27 (XLogP 3.0) |
| Polar surface area | 99.88 Ų |
| H-bond acceptors / donors | 7 / 2 |
| Drug-likeness (QED) | 0.50 |
| Lipinski violations | 0 |
SMILES
CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1ClBiology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | No |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Substrate | — |
| CYP2B6 | Inhibitor | — |
| CYP2C19 | Inhibitor | — |
| CYP2C8 | Inhibitor | — |
| CYP3A4 | Inhibitor | — |
| CYP3A4 | Substrate | — |
Receptor binding (top 1)
| Target | Action | Affinity |
|---|---|---|
| Cav1.3 (CACNA1D) | Gating inhibitor | pIC50 7.2 |
Transporters
ASBT (Inhibitor)BCRP (Inhibitor)BCRP (Inhibitor)BSEP (Inhibitor)BSEP (Inhibitor)MDR1 (Inhibitor)MRP1 (Inhibitor)MRP2 (Inhibitor)MRP3 (Inhibitor)MRP4 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP1B3 (Inhibitor)OCTN2 (Inhibitor)P-gp (Inhibitor)MDR1 (Substrate)P-gp (Substrate)
Drug–drug interactions (100+, DDInter)
| Interacting drug | Severity | Management |
|---|---|---|
| Apalutamide | major | |
| Ceritinib | major | |
| Dolasetron | major | |
| Enzalutamide | major | |
| Lumacaftor | major | |
| Mitotane | major | |
| Simvastatin | major | |
| Siponimod | major | |
| Acalabrutinib | moderate | |
| Acetylsalicylic acid | moderate | |
| Adalimumab | moderate | |
| Aldesleukin | moderate | |
| Alefacept | moderate | |
| Alimemazine | moderate | |
| Amifostine | moderate | |
| Anakinra | moderate | |
| Apixaban | moderate | |
| Aprepitant | moderate | |
| Axitinib | moderate | |
| Betamethasone | moderate | |
| Bexarotene | moderate | |
| Bosutinib | moderate | |
| Brigatinib | moderate | |
| Brimonidine (ophthalmic) | moderate | |
| Brimonidine (topical) | moderate | |
| Budesonide | moderate | |
| Bupropion | moderate | |
| Calcium Phosphate | moderate | |
| Calcium acetate | moderate | |
| Calcium carbonate | moderate | |
| Calcium chloride | moderate | |
| Calcium citrate | moderate | |
| Calcium glubionate anhydrous | moderate | |
| Calcium glucoheptonate | moderate | |
| Calcium gluconate | moderate | |
| Calcium lactate | moderate | |
| Canagliflozin | moderate | |
| Canakinumab | moderate | |
| Certolizumab pegol | moderate | |
| Chloramphenicol | moderate |
Showing 40 of 100+.
Registered Products (174)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Lowrac | Capsule 5 mg | 14 cap pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 2.090 |
| Amlocard- | Tablet 5 mg | 14 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 2.140 |
| Hypodipine Capsules | Capsule 5 mg | 14 cap pack varies | MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN | 2.140 |
| Lowvasc Capsule | Capsule 5 mg | 14 cap pack varies | The Arab Pharmaceutical Manufacturing PSC/Salt | 2.140 |
| Amcardia-5 | Tablet 5 mg | 30 tab pack varies | Roya Tholathiyat Al Abaad Drug Store | 2.760 |
| Amcardia-10 | Tablet 10 mg | 30 tab | Roya Tholathiyat Al Abaad Drug Store | 2.990 |
| Amopress | Tablet 5 mg | 28 tab | Ibn Rushd Drug Store | 3.010 |
| Amlophar | Tablet 5 mg | 30 tab | Professional Drug Store | 3.220 |
| Lofral | Tablet 10 mg | 30 tab | Khoury Drug Store | 3.220 |
| Lofral | Tablet 5 mg | 30 tab | Khoury Drug Store | 3.220 |
| Vaznor | Tablet 5 mg | 30 tab pack varies | Al-Taqqadom Pharmaceutical Industries | 3.220 |
| Vaznor | Tablet 10 mg | 30 tab pack varies | Al-Taqqadom Pharmaceutical Industries | 3.220 |
| Lowrac | Capsule 5 mg | 28 cap pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 3.980 |
| Amlocard- | Tablet 5 mg | 28 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 4.080 |
| Amlodar Cap | Capsule 5 mg | 28 cap pack varies | Dar Al Dawa Development and Investment Co Ltd/Jordan | 4.080 |
| Amlodar Cap | Capsule 10 mg | 28 cap pack varies | Dar Al Dawa Development and Investment Co Ltd/Jordan | 4.080 |
| Hypodipine Capsules | Capsule 5 mg | 28 cap pack varies | MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN | 4.080 |
| Lowvasc capsule | Capsule 5 mg | 28 cap pack varies | The Arab Pharmaceutical Manufacturing PSC/Salt | 4.080 |
| Lowvasc tablet | Tablet 2.5 mg | 28 tab | The Arab Pharmaceutical Manufacturing PSC/Salt | 4.080 |
| Myodipine Cap | Capsule 5 mg | 28 cap pack varies | Hayat Pharmaceutical Industries CO.PLC/JORDAN | 4.080 |
| Amlocard | Tablet 10 mg | 30 tab | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 4.370 |
| Amlopin | Tablet 5 mg | 30 tab pack varies | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 4.370 |
| Amlopin | Capsule 10 mg | 30 cap | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 4.370 |
| Diplow 10 | Tablet 10 mg | 30 tab pack varies | Jordan Sweden Medical & Sterilization Co. | 4.370 |
| Diplow 5 | Tablet 5 mg | 30 tab pack varies | Jordan Sweden Medical & Sterilization Co. | 4.370 |
| Duactin cap | Capsule (Besylate) 5 mg | 30 cap pack varies | Pharma International Company/ Jordan | 4.370 |
| Lowrac 10 | Tablet 10 mg | 30 tab | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 4.370 |
| Myodipine | Tablet 5 mg | 30 tab pack varies | Hayat Pharmaceutical Industries CO.PLC/JORDAN | 4.370 |
| Myodipine | Tablet 10 mg | 30 tab | Hayat Pharmaceutical Industries CO.PLC/JORDAN | 4.370 |
| Tenoryl Plus | Tablet 5 mg, 5 mg | 30 tab | Sukhtian Group | 4.580 |
| Tenoryl Plus | Tablet 10 mg, 5 mg | 30 tab | Sukhtian Group | 4.580 |
| Norvasc | Capsule as Besylate 10 mg | 30 cap | Sabbagh Drug Store | 4.600 |
| Norvasc Caps | Capsule 5 mg | 30 cap | Sabbagh Drug Store | 4.600 |
| Tenoryl Plus | Tablet 10 mg, 10 mg | 30 tab | Sukhtian Group | 6.230 |
| Triplixam 5mg/1.25mg/5mg | Tablet 1.25 mg, 5 mg, 5 mg | 30 tab | The Jordan Drugstore Co | 7.030 |
| Triplixam 5mg /1.25mg /10 mg | Film-Coated Tablet 1.25 mg, 10 mg, 5 mg | 30 Film | The Jordan Drugstore Co | 7.100 |
| Coveram 5+ | Tablet 10 mg, 5 mg | 30 tab | The Jordan Drugstore Co | 7.130 |
| Coveram 5+5 mg Tab | Tablet 5 mg, 5 mg | 30 tab | The Jordan Drugstore Co | 7.130 |
| Lotevan | Tablet 160 mg, 5 mg | 30 tab | Sukhtian Group | 7.850 |
| Lotevan | Tablet 160 mg, 10 mg | 30 tab | Sukhtian Group | 7.850 |
| Lodiva | Tablet Amlodipine Besylate 6.935 mg, Valsartan 160.00 mg | 30 tab | Professional Drug Store | 7.960 |
| Lodiva | Tablet Amlodipine Besylate 13.870 mg, Valsartan 160.00 mg | 30 tab | Professional Drug Store | 7.960 |
| Natrixam 1.5mg/10mg | Tablet 1.5 mg, 10 mg | 30 tab | The Jordan Drugstore Co | 7.990 |
| Natrixam 1.5mg/5mg | Tablet 1.5 mg, 5 mg | 30 tab | The Jordan Drugstore Co | 7.990 |
| Lotevan Plus Film Coated Tablets 5/160/12.5 | Film-Coated Tablet 12.5 mg, 160 mg, 5 mg | 30 tab | Sukhtian Group | 8.010 |
| Lotevan Plus Film Coated Tablets 5/160/25 | Film-Coated Tablet 25 mg, 160 mg, 5 mg | 30 tab | Sukhtian Group | 8.010 |
| Lotevan Plus Film Coated Tablets 10/160/12.5 | Film-Coated Tablet 12.5 mg, 160 mg, 10 mg | 30 tab | Sukhtian Group | 8.120 |
| Lotevan Plus Film Coated Tablets 10/160/25 | Film-Coated Tablet 25 mg mg, 160 mg, 10 mg | 30 tab | Sukhtian Group | 8.120 |
| TWINTAB 80/5 (Telmisartan and Amlodipine Tablets 80/5mg) Tablet | Tablet Telmisartan 80 mg, Amlodipine 5 mg | 30 tab | Al-Motakadema Pharmaceutical LTD. | 8.600 |
| TWINTAB 80/10 (Telmisartan and Amlodipine Tablets 80/10mg) Tablet | Tablet Telmisartan 80 mg, Amlodipine 10 mg | 30 tab | Al-Motakadema Pharmaceutical LTD. | 8.630 |
| Senergy | Tablet 160 mg, 5 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 8.680 |
| Senergy 10/160 mg F.C Tab | Film-Coated Tablet 160 mg, 10 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 8.680 |
| ValHart TRIO 5/160/12.5mg FC Tablets | Film-Coated Tablet 12.5 mg, 160.00 mg, 6.935 mg | 30 tab | Petra Pharmaceutical Industries | 8.690 |
| Valhart DUO | Tablet Valsartan 160.00 mg, Amlodipine Besylate 13.87 mg | 30 tab | Petra Pharmaceutical Industries | 8.690 |
| Valhart DUO | Tablet Amlodipine Besylate 6.935 mg, Valsartan 160.00 mg | 30 tab | Petra Pharmaceutical Industries | 8.690 |
| Mextra | Tablet 8 mg, 5 mg | 30 tab | JORDAN RIVER PHARMA.IND(JORIVER)/JORDAN | 8.780 |
| Mextra | Tablet 8 mg, 2.5 mg | 30 tab | JORDAN RIVER PHARMA.IND(JORIVER)/JORDAN | 8.780 |
| Senergy Plus (5/160/25) Mg F.C Tab | Film-Coated Tablet 25 mg, 160 mg, 5 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 8.780 |
| Senergy Plus(5/160/12.5) mg F.c Tab | Film-Coated Tablet 12.5 mg, 160 mg, 5 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 8.780 |
| Dimovasc | Tablet 160 mg, 10 mg | 30 tab | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 8.820 |
| Dimovasc | Tablet 160 mg, 5 mg | 30 tab | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 8.820 |
| Dimovasc | Tablet 80 mg, 5 mg | 30 tab | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 8.820 |
| Angiosar 160/10 F.C Tab | Film-Coated Tablet 160 mg, as Besylate 10 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 9.050 |
| Angiosar 160/5 F.C Tab | Film-Coated Tablet 160 mg, as Besylate 5 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 9.050 |
| SEVIKAR 20/5 | Tablet 5 mg, 20 mg | 28 tab | Salam Drug Store | 9.120 |
| ValHart TRIO 10/160/12.5mg FC Tablets | Film-Coated Tablet 12.5 mg, 160.00 mg, 13.87 mg | 30 tab | Petra Pharmaceutical Industries | 9.160 |
| Co-act 5/10 mg F.C Tab | Film-Coated Tablet 10 mg, 5 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 9.310 |
| Joswe Dubara | Tablet 10 mg, 5 mg | 30 tab | Jordan Sweden Medical & Sterilization Co. | 9.310 |
| Joswe Dubara | Tablet 10 mg, 10 mg | 30 tab | Jordan Sweden Medical & Sterilization Co. | 9.310 |
| Monteer 10/10mg F.C Tab | Film-Coated Tablet as Calcium 10 mg, as Besylate 10 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 9.310 |
| Monteer 5/10 mg F.C Tab | Film-Coated Tablet as Calcium 10 mg, as Besylate 5 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 9.310 |
| Ezlorg | Tablet 160 mg, 5 mg | 28 tab | SAVVY PHARMA/JORDAN | 9.420 |
| Ezlorg | Tablet 160 mg, 10 mg | 28 tab | SAVVY PHARMA/JORDAN | 9.420 |
| Newstar 160/10mg F.C Tab | Film-Coated Tablet 160 mg, 10 mg | 28 tab | Pharma International Company/ Jordan | 9.420 |
| Newstar 160/5mg F/C tab | Tablet 160 mg, 5 mg | 28 tab | Pharma International Company/ Jordan | 9.420 |
| Coveram 10 + | Tablet 5 mg, 10 mg | 30 tab | The Jordan Drugstore Co | 9.700 |
| Coveram 10+ 10 | Tablet 10 mg, 10 mg | 30 tab | The Jordan Drugstore Co | 9.700 |
| Unipress | Tablet Amlodipine Besylate 5.00 mg, Candesartan Cilexetil 16.00 mg | 30 tab | The Arab Pharmaceutical Manufactruing Co | 9.790 |
| Unipress | Tablet Amlodipine Besylate 10.00 mg, Candesartan Cilexetil 16.00 mg | 30 tab | The Arab Pharmaceutical Manufactruing Co | 9.790 |
| Combitran | Tablet 6.935 mg, 20 mg | 30 tab | pharma international | 10.090 |
| Joswe Potenza | Tablet 160 mg, 10 mg | 30 tab | Jordan Sweden Medical & Sterilization Co. | 10.090 |
| Joswe Potenza | Tablet 80 mg, 5 mg | 30 tab | Jordan Sweden Medical & Sterilization Co. | 10.090 |
| Joswe Potenza | Tablet 160 mg, 5 mg | 30 tab | Jordan Sweden Medical & Sterilization Co. | 10.090 |
| Mextra | Tablet 16 mg, 5 mg | 30 tab | JORDAN RIVER PHARMA.IND(JORIVER)/JORDAN | 10.160 |
| Senergy Plus(10/160/12.5) mg F.C Tab | Film-Coated Tablet 12.5 mg, 160 mg, 10 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 10.250 |
| Senergy Plus(10/320/25) Mg F.C Tab | Film-Coated Tablet 25 mg, 320 mg, 10 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 10.250 |
| Senergy plus (10/160/25) mg F.C Tab | Film-Coated Tablet 25 mg, 160 mg, 10 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 10.250 |
| Caduet | Tablet 10 mg, 5 mg | 30 tab | Sabbagh Drug Store | 10.340 |
| Caduet | Tablet 10 mg, 10 mg | 30 tab | Sabbagh Drug Store | 10.340 |
| Gizlan Duo | Tablet 300 mg, 10 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 10.340 |
| Gizlan Duo | Tablet 150 mg, 10 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 10.340 |
| Gizlan Duo | Tablet 150 mg, 5 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 10.340 |
| Gizlan Duo | Film-Coated Tablet 300 mg, 5 mg | 30 Film | Dar Al Dawa Development and Investment Co Ltd/Jordan | 10.340 |
| SEVIKAR 40/5 | Tablet 5 mg, 40 mg | 28 tab | Salam Drug Store | 10.370 |
| Acloran | Tablet 10 mg, 16 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 10.640 |
| Acloran | Tablet 8 mg, 2.5 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 10.640 |
| Acloran | Tablet 16 mg, 5 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 10.640 |
| Acloran | Tablet 8 mg, 5 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 10.640 |
| Angiosar Plus 160/10/12.5 f.c tab | Film-Coated Tablet 12.5 mg, 160 mg, 10 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 10.690 |
| Angiosar-Plus | Tablet 25 mg, 320 mg, 10 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 10.690 |
| Angiosar-Plus 160/5/12.5 F.C Tab | Film-Coated Tablet 12.5 mg, 160 mg, 5 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 10.690 |
| Angiosar-plus160/5/25 F.C tab | Film-Coated Tablet 25 mg, 160 mg, 5 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 10.690 |
| Combitran Plus | Tablet 12.5 mg, 10 mg, 40 mg | 30 tab | Pharma International Company/ Jordan | 10.940 |
| Combitran Plus | Tablet 12.5 mg, 5 mg, 40 mg | 30 tab | Pharma International Company/ Jordan | 10.940 |
| Newstar Plus | Tablet 25 mg, 10 mg, 160 mg | 28 tab | Pharma International Company | 11.030 |
| Newstar Plus | Tablet 12.5 mg, 10 mg, 160 mg | 28 tab | pharma international | 11.030 |
| Newstar Plus | Tablet 25 mg, 5 mg, 160 mg | 28 tab | pharma international | 11.030 |
| Newstar Plus | Tablet 12.5 mg, 5 mg, 160 mg | 28 tab | pharma international | 11.030 |
| Combizart | Tablet 10 mg, 20 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 11.100 |
| Combizart | Tablet 5 mg, 20 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 11.100 |
| Combizart | Tablet 5 mg, 40 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 11.100 |
| Combizart 40mg/10mg | Tablet 10 mg, 40 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 11.100 |
| Combizart HCT | Tablet 25 mg, 5 mg, 40 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 11.100 |
| Combizart HCT | Tablet 12.5 mg, 5 mg, 40 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 11.100 |
| Combizart HCT | Tablet 25 mg, 10 mg, 40 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 11.100 |
| Combizart HCT | Tablet 12.5 mg, 10 mg, 40 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 11.100 |
| Combizart HCT | Tablet 12.5 mg, 5 mg, 20 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 11.100 |
| Combitran | Tablet 6.935 mg, 40 mg | 30 tab | pharma international | 11.120 |
| SEVIKAR 40/10 | Tablet 10 mg, 40 mg | 28 tab | Salam Drug Store | 11.150 |
| Exforge | Tablet 160 mg, 10 mg | 28 tab | The Jordan Drugstore Co | 11.590 |
| Exforge | Tablet 80 mg, 5 mg | 28 tab | The Jordan Drugstore Co | 11.590 |
| Exforge | Tablet 160 mg, 5 mg | 28 tab | The Jordan Drugstore Co | 11.590 |
| Exforge HCT 5/160/12.5 | Tablet 12.5 mg, 160 mg, 5 mg | 28 tab | The Jordan Drugstore Co | 11.590 |
| Exforge HCT 5/160/25 | Tablet 25 mg, 160 mg, 5 mg | 28 tab | The Jordan Drugstore Co | 11.590 |
| Tepresta | Tablet 80 mg, 5 mg | 30 tab | SANA PHARMACEUTICAL INDUSTRY/JORDAN | 12.070 |
| Exforge HCT 10/160/12.5 | Tablet 12.5 mg, 160 mg, 10 mg | 28 tab | The Jordan Drugstore Co | 12.220 |
| Exforge HCT 10/160/25 | Tablet 25 mg, 160 mg, 10 mg | 28 tab | The Jordan Drugstore Co | 12.220 |
| VAZALDO | Tablet 10 mg, 10 mg | 30 tab | / UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN / General | 12.610 |
| VAZALDO | Tablet 5 mg, 10 mg | 30 tab | / UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN / General | 12.610 |
| Joswe Potenza Plus | Tablet 12.5 mg, 160 mg, 5 mg | 30 tab | Jordan Sweden Medical & Sterilization Co. | 12.810 |
| Vocado 20mg/5mg F.c Tab | Film-Coated Tablet as besilate 5 mg, 20 mg | 28 tab | ORIENT DRUG STORE CO | 12.850 |
| Co-act 5/20mg F.C Tab | Film-Coated Tablet 20 mg, 5 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 12.930 |
| Joswe Dubara | Tablet 20 mg, 5 mg | 30 tab | Jordan Sweden Medical & Sterilization Co. | 12.930 |
| Co-act 10/20 mg F.c Tab | Film-Coated Tablet 20 mg, 10 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 12.970 |
| Joswe Dubara | Tablet 20 mg, 10 mg | 30 tab | Jordan Sweden Medical & Sterilization Co. | 12.970 |
| Lotevan | Tablet 320 mg, 5 mg | 30 tab | Sukhtian Group | 13.140 |
| Tepresta | Tablet 80 mg, 10 mg | 30 tab | Sana pharmaceutical industry | 13.250 |
| Lotevan 320 /10 tab | Tablet 320 mg, 10 mg | 30 tab | Sukhtian Group | 13.320 |
| Lotevan Plus Film Coated Tablets 10/320/25 | Film-Coated Tablet 25 mg mg, 320 mg, 10 mg | 30 tab | Sukhtian Group | 13.320 |
| Vocado 40mg/10mg F.C Tab | Film-Coated Tablet as besilate 10 mg, 40 mg | 28 tab | ORIENT DRUG STORE CO | 13.650 |
| Vocado 40mg/5mg F.C Tab | Film-Coated Tablet as besilate 5 mg, 40 mg | 28 tab | ORIENT DRUG STORE CO | 13.650 |
| Vocado HCT 20/5/12.5 mg F.C Tab | Film-Coated Tablet 12.5 mg, 5 mg, 20 mg | 28 tab | ORIENT DRUG STORE CO | 13.650 |
| Vocado HCT 40/10/12.5 mg F.C tab | Film-Coated Tablet 12.5 mg, 10 mg, 40 mg | 28 tab | ORIENT DRUG STORE CO | 13.650 |
| Vocado HCT 40/10/25 mg F.C Tab | Film-Coated Tablet 25 mg, 10 mg, 40 mg | 28 tab | ORIENT DRUG STORE CO | 13.650 |
| Vocado HCT 40/5/12.5 mg F.C Tab | Film-Coated Tablet 12.5 mg, 5 mg, 40 mg | 28 tab | ORIENT DRUG STORE CO | 13.650 |
| Vocado HCT 40/5/25 mg F.C Tab | Film-Coated Tablet 25 mg, 5 mg, 40 mg | 28 tab | ORIENT DRUG STORE CO | 13.650 |
| Co-act 10/40 mg F.C Tab | Film-Coated Tablet 40 mg, 10 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 13.770 |
| Co-act 5/40 mg F.C Tab | Film-Coated Tablet 40 mg, 5 mg | 30 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 13.770 |
| Triplixam 10mg/2.5mg/10mg | Tablet 2.5 mg, 10 mg, 10 mg | 30 tab | The Jordan Drugstore Co | 13.930 |
| Triplixam 10mg/2.5mg/5mg | Tablet 2.5 mg, 5 mg, 10 mg | 30 tab | The Jordan Drugstore Co | 13.930 |
| Caduet | Tablet 20 mg, 5 mg | 30 tab | Sabbagh Drug Store | 14.370 |
| Caduet | Tablet 20 mg, 10 mg | 30 tab | Sabbagh Drug Store | 14.410 |
| VAZALDO | Tablet 5 mg, 20 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 14.570 |
| VAZALDO | Tablet 10 mg, 20 mg | 30 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 14.570 |
| Caduet | Tablet 40 mg, 5 mg | 30 tab | Sabbagh Drug Store | 15.300 |
| Caduet | Tablet 40 mg, 10 mg | 30 tab | Sabbagh Drug Store | 15.300 |
| Twynsta 80mg/5mg | Tablet 80 mg, 5 mg | 28 tab | The Jordan Drugstore Co | 15.450 |
| Twynsta 80mg/10mg | Tablet 80 mg, 10 mg | 28 tab | The Jordan Drugstore Co | 16.960 |
| Joswe Potenza Plus | Tablet 25 mg, 320 mg, 10 mg | 30 tab | Jordan Sweden Medical & Sterilization Co. | 19.050 |
| Joswe Dubara | Tablet 80 mg, 10 mg | 30 tab | Jordan Sweden Medical & Sterilization Co. | 34.040 |
| Hypodipine Capsules | Capsule 5 mg | 350 cap pack varies | MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN | 45.390 |
| Amlodar Cap | Capsule 10 mg | 490 cap pack varies | Dar Al Dawa Development and Investment Co Ltd/Jordan | 62.120 |
| Amlodar Cap | Capsule 5 mg | 490 cap pack varies | Dar Al Dawa Development and Investment Co Ltd/Jordan | 62.120 |
| Amlopin | Tablet 5 mg | 500 tab pack varies | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 63.360 |
| Duactin cap | Capsule (Besylate) 5 mg | 500 cap pack varies | Pharma International Company/ Jordan | 63.360 |
| Myodipine Tab | Tablet 5 mg | 510 tab pack varies | Hayat Pharmaceutical Industries CO.PLC/JORDAN | 64.630 |
| Amcardia-5 | Tablet 5 mg | 1000 tab pack varies | Roya Tholathiyat Al Abaad Drug Store | 78.200 |
| Myodipine Cap | Capsule 5 mg | 700 cap pack varies | Hayat Pharmaceutical Industries CO.PLC/JORDAN | 86.700 |
| Vaznor | Tablet 10 mg | 1000 tab pack varies | Al-Taqqadom Pharmaceutical Industries | 91.230 |
| Vaznor | Tablet 5 mg | 1000 tab pack varies | Al-Taqqadom Pharmaceutical Industries | 91.230 |
| Myodipine | Tablet 5 mg | 960 tab pack varies | Hayat Pharmaceutical Industries CO.PLC/JORDAN | 118.860 |
| Amlocard- | Tablet 5 mg | 994 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 123.110 |
| Diplow 10 | Tablet 10 mg | 1050 tab pack varies | Jordan Sweden Medical & Sterilization Co. | 130.010 |
| Diplow 5 | Tablet 5 mg | 1050 tab pack varies | Jordan Sweden Medical & Sterilization Co. | 130.010 |